Restylane Dermal Fillers
A trusted family of hyaluronic acid fillers by Galderma, with over 50 million treatments performed worldwide and nine specialized formulas for every facial area.
What Is Restylane?
Restylane is a family of FDA-approved hyaluronic acid dermal fillers by Galderma, with over 50 million treatments performed worldwide across 100+ countries. The portfolio includes nine specialized formulas using NASHA and OBT technology -- including Kysse for lips, Lyft for cheeks and hands, and Eyelight for under-eye hollows. As one of the first HA fillers approved in the U.S. (2003), Restylane has one of the longest safety track records in aesthetic medicine.
What Is Restylane?
Restylane is a family of FDA-approved hyaluronic acid (HA) dermal fillers manufactured by Galderma, one of the world's largest dermatology companies. As one of the first HA fillers approved in the United States (in 2003), Restylane has an exceptionally long track record of safety and effectiveness, with over 50 million treatments performed worldwide across more than 100 countries.
The Restylane portfolio has grown to include nine specialized formulas, each designed with a unique gel texture and particle size tailored to specific treatment areas. Whether you are seeking lip enhancement, cheek volume, under-eye correction, or wrinkle smoothing, there is a Restylane product engineered for that purpose.
Like all HA fillers, Restylane works by adding volume to the skin using hyaluronic acid -- a substance your body produces naturally. HA attracts and retains moisture, which helps restore the plump, hydrated look that diminishes with age. Because it uses a biocompatible material, Restylane can be dissolved with hyaluronidase if needed, providing an important safety advantage.
Restylane Technologies
Galderma has developed three distinct manufacturing technologies for the Restylane family, each creating a different gel structure optimized for specific treatment needs:
NASHA
Non-Animal Stabilized Hyaluronic Acid. The original technology used in classic Restylane and Restylane Lyft. NASHA creates a firm, particulate gel that provides strong structural support and definition. Ideal for areas that need robust volume and lift.
OBT
Optimal Balance Technology. Used in Restylane Eyelight. OBT produces a softer, more flexible gel that integrates gently into tissue, reducing the risk of visible lumps. Specifically designed for the delicate under-eye area.
XpresHAn
Used in Restylane Kysse, Defyne, Refyne, and Contour. XpresHAn Technology creates a flexible, dynamic gel that moves naturally with facial expressions -- stretching, compressing, and bouncing back rather than remaining rigid.
The Complete Restylane Product Line
Restylane / Restylane-L
NASHAThe original and most versatile formula. Used for moderate facial wrinkles, nasolabial folds, and lip enhancement. Restylane-L includes lidocaine for added comfort during injection. This classic formulation has the longest safety track record in the portfolio.
Duration: 6-12 months | Treatment areas: Lips, nasolabial folds, wrinkles
Restylane Lyft
NASHAA firmer formulation designed for deeper injection to restore midface volume and correct age-related cheek flattening. Restylane Lyft is also the first and only FDA-approved HA filler for hand rejuvenation, restoring volume to the back of aging hands.
Duration: Up to 12 months (face), 6 months (hands) | Treatment areas: Cheeks, midface, hands
Restylane Silk
NASHAFormulated with smaller, smoother particles specifically for subtle lip enhancement and the correction of fine lines around the mouth (perioral lines). Restylane Silk was the first FDA-approved product specifically designed for lip augmentation and perioral wrinkles.
Duration: 6-12 months | Treatment areas: Lips, perioral lines
Restylane Kysse
XpresHAnThe gold standard for lip augmentation. Kysse uses XpresHAn Technology to create lips that look and feel natural during movement -- smiling, talking, and kissing. It provides lasting volume and color enhancement while maintaining a soft, flexible texture that moves with your expressions.
Duration: Up to 12 months | Treatment areas: Lips, upper lip lines
Restylane Refyne
XpresHAnDesigned for mild to moderate nasolabial folds and marionette lines. Refyne's flexible gel allows natural facial movement while softening laugh lines. It is the lighter option in the XpresHAn lineup, ideal for patients with early signs of aging.
Duration: Up to 12 months | Treatment areas: Mild nasolabial folds, marionette lines
Restylane Defyne
XpresHAnThe more robust XpresHAn formula for moderate to severe nasolabial folds and marionette lines. Defyne provides greater lifting power while still maintaining flexibility and natural movement. It bridges the gap between soft fillers and structural volumizers.
Duration: Up to 12 months | Treatment areas: Moderate-severe nasolabial folds, marionette lines
Restylane Contour
XpresHAnSpecifically designed for cheek augmentation and midface contouring. Contour uses XpresHAn Technology so the cheeks maintain natural movement during smiling and other expressions, avoiding the "frozen" or overfilled appearance that can occur with firmer fillers.
Duration: Up to 12 months | Treatment areas: Cheeks, midface
Restylane Eyelight
OBTThe only Restylane product using OBT technology, specifically designed for the delicate under-eye area (tear troughs). Eyelight addresses dark circles, hollowing, and shadows beneath the eyes with a soft gel that minimizes the risk of the Tyndall effect (bluish discoloration) that can occur with other fillers in this area.
Duration: Up to 18 months | Treatment areas: Under-eyes (tear troughs)
Key Facts at a Glance
Hyaluronic Acid
Duration Range
Treatments Worldwide
Reversible
What Makes Restylane Unique
While many HA fillers compete in the same spaces, Restylane offers several distinctive advantages:
- Broadest product portfolio: Nine formulas covering every major treatment area, including the only FDA-approved HA filler for hands (Lyft) and a dedicated under-eye filler (Eyelight).
- XpresHAn Technology: A unique cross-linking process that allows the gel to adapt to facial movement, maintaining natural expressions even in high-movement areas like the lips and smile lines.
- Longest safety track record: Over 20 years on the US market with 50+ million treatments, providing extensive real-world safety data.
- Restylane Eyelight: One of the few fillers specifically FDA-approved for under-eye hollows, an area that requires special formulation to avoid visible lumps or discoloration.
Frequently Asked Questions About Restylane
How long does Restylane last?
Restylane results vary by product. The original Restylane and Restylane-L last 6-12 months, Restylane Lyft lasts up to 12 months in the face and 6 months in the hands, Restylane Kysse lasts up to 12 months, and Restylane Eyelight can last up to 18 months. Individual results depend on the treatment area, your metabolism, and lifestyle factors like sun exposure and exercise.
What makes Restylane Kysse special for lips?
Restylane Kysse uses XpresHAn Technology, which creates a flexible gel that moves naturally with your lips during speech, smiling, and kissing. Unlike firmer fillers, Kysse maintains a soft, natural feel while providing lasting volume and definition. It was specifically designed and FDA-approved for lip augmentation and upper lip lines, making it one of the most popular choices for lip enhancement.
Can Restylane treat under-eye hollows?
Yes. Restylane Eyelight is specifically FDA-approved for treating under-eye hollows (tear troughs). It uses OBT technology to create a smooth, soft gel that integrates well in the delicate under-eye area with minimal risk of visible lumps or the Tyndall effect (bluish discoloration). This makes it one of the few fillers specifically indicated for this sensitive area.
Is Restylane the same as Juvederm?
Both are hyaluronic acid fillers used for similar purposes, but they are made by different companies using different technologies. Restylane is made by Galderma using NASHA, OBT, and XpresHAn technology, while Juvederm is made by Allergan using VYCROSS and Hylacross technology. Both produce excellent results, and many providers use both brands depending on the treatment area and patient goals.
How much does Restylane cost?
Restylane products typically cost between $500 and $1,000 per syringe. The total cost depends on the specific product, the number of syringes needed, and your geographic location. Lip treatments generally require 1 syringe, while cheek and midface treatments may require 1-2 syringes per side. Galderma offers the ASPIRE Galderma Rewards program, which provides points toward savings on future Restylane and Dysport treatments.
What are the side effects of Restylane?
Common side effects include temporary swelling, redness, pain, bruising, and tenderness at the injection site. These typically resolve within 7 days. Less common side effects include itching, discoloration, and firmness at the injection site. Serious side effects are rare when treatment is performed by a qualified provider who understands proper injection techniques and facial anatomy.
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